Epitalon (Epithalon)
Epitalon (the AEDG tetrapeptide) has been studied for inducing telomerase catalytic-subunit expression and telomere elongation in telomerase-negative human fibroblast cultures, and for normalizing cir...
Sequence
Mechanism of Action
Epitalon (the AEDG tetrapeptide) has been studied for inducing telomerase catalytic-subunit expression and telomere elongation in telomerase-negative human fibroblast cultures, and for normalizing circadian melatonin and cortisol secretion in aged primates. Molecular modeling suggests it may bind histone H1 sites to epigenetically regulate transcription. Its telomerase-inducing effect raises a theoretical oncogenesis concern — telomerase reactivation is a hallmark of many cancers — though the origin research group's own animal work reports decreased experimental carcinogenesis with treatment, a tension not yet independently resolved outside that group. No completed human clinical safety trials were identified; the evidence base is limited to in vitro and animal studies from a small number of research groups.