Epitalon (the AEDG tetrapeptide) has been studied for inducing telomerase catalytic-subunit expression and telomere elongation in telomerase-negative human fibroblast cultures, and for normalizing cir...
Epitalon (the AEDG tetrapeptide) has been studied for inducing telomerase catalytic-subunit expression and telomere elongation in telomerase-negative human fibroblast cultures, and for normalizing circadian melatonin and cortisol secretion in aged primates. Molecular modeling suggests it may bind histone H1 sites to epigenetically regulate transcription. Its telomerase-inducing effect raises a theoretical oncogenesis concern — telomerase reactivation is a hallmark of many cancers — though the origin research group's own animal work reports decreased experimental carcinogenesis with treatment, a tension not yet independently resolved outside that group. No completed human clinical safety trials were identified; the evidence base is limited to in vitro and animal studies from a small number of research groups.
Aging (Albany NY) · 2022
Epitalon reduced intracellular reactive oxygen species and increased mitochondrial membrane potential in aging mouse oocytes.
View Source →Molecules · 2020
AEDG increased neurogenic differentiation markers in human gingival stem cells and was modeled to bind histone H1.3/H1.6 sites, suggesting an epigenetic mechanism.
View Source →Bulletin of Experimental Biology and Medicine · 2003
Addition of Epithalon to telomerase-negative human fetal fibroblast culture induced telomerase catalytic-subunit expression, enzymatic activity, and telomere elongation.
View Source →Bulletin of Experimental Biology and Medicine · 2001
In aged female rhesus monkeys, Epithalon stimulated evening melatonin production and normalized circadian cortisol rhythms.
View Source →