Not FDA-Approved — Research Use Only
Kisspeptin
Kisspeptin binds the KISS1 receptor (KISS1R/GPR54) on hypothalamic GnRH neurons, triggering phospholipase C activation, closure of potassium channels, and sustained depolarization — positioning it as ...
PubChem CID25240297
FormulaC63H83N17O14
Mol. Weight1302.4 g/mol
Sequence
Mechanism of Action
Kisspeptin binds the KISS1 receptor (KISS1R/GPR54) on hypothalamic GnRH neurons, triggering phospholipase C activation, closure of potassium channels, and sustained depolarization — positioning it as the principal upstream regulator of pulsatile and surge GnRH release, and consequently of downstream LH/FSH secretion. A nonneuronal KISS1R pathway in astrocytes has also been identified that modulates the reproductive axis indirectly.
KISS1 receptor (KISS1R/GPR54)