Not FDA-Approved — Research Use Only

MOTS-c

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene — a "mitochondrial-derived peptide." It signals to skeletal muscle, suppressing folate-linked purine synthesis and acti...

PubChem CID146675088
FormulaC101H152N28O22S2
Mol. Weight2174.6 g/mol

Sequence

Mechanism of Action

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene — a "mitochondrial-derived peptide." It signals to skeletal muscle, suppressing folate-linked purine synthesis and activating AMPK; exercise induces endogenous MOTS-c, and exogenous dosing in mice mimics exercise-associated metabolic benefits including improved insulin sensitivity. No established human safety or dosing data exist for exogenous administration — human evidence to date is limited to measuring endogenous expression during exercise, not administering the peptide itself.

AMPK activation (skeletal muscle)Folate cycle / purine biosynthesis inhibition

Research Literature