MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene — a "mitochondrial-derived peptide." It signals to skeletal muscle, suppressing folate-linked purine synthesis and acti...
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene — a "mitochondrial-derived peptide." It signals to skeletal muscle, suppressing folate-linked purine synthesis and activating AMPK; exercise induces endogenous MOTS-c, and exogenous dosing in mice mimics exercise-associated metabolic benefits including improved insulin sensitivity. No established human safety or dosing data exist for exogenous administration — human evidence to date is limited to measuring endogenous expression during exercise, not administering the peptide itself.
Nature Communications · 2021
Enhanced physical performance in mice across ages; exercise induced endogenous MOTS-c in human muscle and blood, the primary human evidence available for this compound.
View Source →Cell Metabolism · 2015
Identified the MOTS-c sequence encoded in mitochondrial DNA; prevented age- and diet-induced insulin resistance and diet-induced obesity in mice.
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