Not FDA-Approved — Research Use Only
Semax
Semax is a synthetic heptapeptide derived from the ACTH(4-7) sequence with an added Pro-Gly-Pro tail, studied predominantly in rodent models of cerebral ischemia and in human neuroimaging studies of b...
PubChem CID9811102
FormulaC37H51N9O10S
Mol. Weight813.9 g/mol
Sequence
Mechanism of Action
Semax is a synthetic heptapeptide derived from the ACTH(4-7) sequence with an added Pro-Gly-Pro tail, studied predominantly in rodent models of cerebral ischemia and in human neuroimaging studies of brain connectivity. Proposed mechanisms include modulation of neurotrophic signaling, altered hippocampal calcium dynamics, and immune/vascular gene-expression changes in ischemic brain tissue — distinct from ACTH's classical corticotropic hormone activity, which the sequence used here lacks.
BDNF/CREB signaling (proposed)Hippocampal calcium dynamics