Not FDA-Approved — Research Use Only

Glutathione

Oxidized glutathione is an FDA-approved ingredient only in BSS PLUS, a prescription intraocular surgical irrigating solution — unrelated to antioxidant/IV use, which has no FDA drug approval.

Glutathione is the most abundant intracellular low-molecular-weight thiol and the major cellular redox buffer, serving as the essential cofactor for glutathione peroxidase (neutralizing peroxides) and...

PubChem CID124886
FormulaC10H17N3O6S
Mol. Weight307.33 g/mol

Sequence

Mechanism of Action

Glutathione is the most abundant intracellular low-molecular-weight thiol and the major cellular redox buffer, serving as the essential cofactor for glutathione peroxidase (neutralizing peroxides) and glutathione-S-transferases (hepatic xenobiotic conjugation and clearance). A randomized, placebo-controlled trial of IV glutathione in Parkinson's disease found it well tolerated with no significant difference in adverse events from placebo, but no statistically significant motor-symptom benefit. IV glutathione used off-label for skin lightening has documented adverse effects sufficient to prompt a public regulatory warning against that specific use.

Glutathione peroxidaseGlutathione-S-transferases

Research Literature