KPV

Sequence

Mechanism of Action

KPV is the C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (residues 11-13). It is taken up into immune and intestinal epithelial cells via the PepT1 transporter, where nanomolar concentrations suppress NF-kB and MAP kinase-driven pro-inflammatory cytokine production — a mechanism shown to be independent of melanocortin receptors despite KPV's alpha-MSH lineage. It has been studied primarily in mouse models of inflammatory bowel disease; no published human clinical trial data was identified.

Research Literature