No IND or registered human trials exist; all evidence to date is preclinical (mouse).
5-Amino-1MQ is a selective, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes SAM to methylate nicotinamide, depleting cellular SAM and NAD+ pools. Inhib...
5-Amino-1MQ is a selective, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes SAM to methylate nicotinamide, depleting cellular SAM and NAD+ pools. Inhibiting NNMT raises intracellular SAM and NAD+ in adipocytes, suppressing lipogenesis and promoting fat oxidation in mouse models — reducing adiposity without reducing food intake. No human safety or efficacy data exist; the founding mouse study observed no adverse effects during short-term dosing, but that is a single short preclinical study, not a toxicology program.
Scientific Reports · 2022
NNMT inhibition combined with a reduced-calorie diet drove greater weight loss and a distinct gut microbiome versus diet alone in obese mice.
View Source →Biochemical Pharmacology · 2018
Reduced body weight, adipose mass, and plasma cholesterol in diet-induced-obese mice without affecting food intake.
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