5-Amino-1MQ

No IND or registered human trials exist; all evidence to date is preclinical (mouse).

PubChem CID950107

FormulaC10H11N2+

Mol. Weight159.21 g/mol

Mechanism of Action

5-Amino-1MQ is a selective, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes SAM to methylate nicotinamide, depleting cellular SAM and NAD+ pools. Inhibiting NNMT raises intracellular SAM and NAD+ in adipocytes, suppressing lipogenesis and promoting fat oxidation in mouse models — reducing adiposity without reducing food intake. No human safety or efficacy data exist; the founding mouse study observed no adverse effects during short-term dosing, but that is a single short preclinical study, not a toxicology program.

Nicotinamide N-methyltransferase (NNMT) inhibitor

Research Literature

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice

Animal Study

Scientific Reports · 2022

NNMT inhibition combined with a reduced-calorie diet drove greater weight loss and a distinct gut microbiome versus diet alone in obese mice.

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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice

Animal Study

Biochemical Pharmacology · 2018

Reduced body weight, adipose mass, and plasma cholesterol in diet-induced-obese mice without affecting food intake.

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5-AMINO-1MQ