Not FDA-Approved — Research Use Only
Selank
Selank is a synthetic, metabolically stabilized extension of the natural immunomodulatory tetrapeptide tuftsin, studied primarily in rodent models of anxiety, stress, and cognition. Proposed mechanism...
PubChem CID11765600
FormulaC33H57N11O9
Mol. Weight751.9 g/mol
Sequence
Mechanism of Action
Selank is a synthetic, metabolically stabilized extension of the natural immunomodulatory tetrapeptide tuftsin, studied primarily in rodent models of anxiety, stress, and cognition. Proposed mechanisms include upregulation of hippocampal and prefrontal cortical BDNF, modulation of GABAergic signaling, and inhibition of enzymes that degrade endogenous enkephalins. Human data is limited to a single small resting-state fMRI study.
BDNF expression (proposed)GABAergic signaling (proposed)