Selank is a synthetic, metabolically stabilized extension of the natural immunomodulatory tetrapeptide tuftsin, studied primarily in rodent models of anxiety, stress, and cognition. Proposed mechanism...
Selank is a synthetic, metabolically stabilized extension of the natural immunomodulatory tetrapeptide tuftsin, studied primarily in rodent models of anxiety, stress, and cognition. Proposed mechanisms include upregulation of hippocampal and prefrontal cortical BDNF, modulation of GABAergic signaling, and inhibition of enzymes that degrade endogenous enkephalins. Human data is limited to a single small resting-state fMRI study.
Bulletin of Experimental Biology and Medicine · 2022
Selank reduced a composite morphine-withdrawal severity index by roughly 40% and increased pain threshold about 9-fold versus untreated withdrawal controls in rats.
View Source →Doklady Biological Sciences · 2020
Resting-state fMRI study in 52 healthy volunteers randomized to Selank, Semax, or placebo found treatment-specific changes in functional connectivity between the amygdala and temporal/parahippocampal regions.
View Source →Bulletin of Experimental Biology and Medicine · 2019
Selank prevented memory disturbances associated with chronic ethanol exposure and withdrawal in aging rats, an effect linked to regulation of hippocampal and prefrontal BDNF levels.
View Source →Behavioural Neurology · 2017
In elevated-plus-maze testing, Selank's anxiolytic effect was comparable to diazepam alone, with combined treatment most effective under chronic stress.
View Source →